The National Heart Foundation of Australia. B.E.K. is an Australian Research Council Federation fellow. PROGRESS was funded by grants from Servier, the Health Research Council of New Zealand, and the National Health and Medical Research Council of Australia.
The weighted average price per share shall be determined by dividing the aggregate sale price of all such shares sold on the aforementioned exchange or market, as the case may be, during the aforementioned 10 consecutive trading days by the total number of such shares so sold; j ; designated provinces means the provinces of british columbia, ontario and quebec; k ; director means a director of the company for the time being and, unless otherwise specified herein, a reference to an action by the directors means an action by the directors of the company as a board or, whenever duly empowered, action by a committee of such board; l ; dividends paid in the ordinary course means such dividends payable in cash or in securities, property or assets of equivalent value ; declared payable on a common share in any fiscal year of the company to the extent that such dividends in the aggregate do not exceed in amount or value the greater of: i ; 100% of the aggregate amount or value of the dividends declared payable by the company on the common shares in the period of 12 consecutive months ended immediately prior to the first day of such fiscal year; and ii ; 50% of the consolidated net earnings of the company, before extraordinary items and after dividends paid on any and all preferred shares of the company if any ; for the period of 12 consecutive months ended immediately prior to the first day of such fiscal year such consolidated net earnings to be as shown in the audited consolidated financial statements of the company for such 12 month period or, if there are no audited financial statements in respect of such period, computed in accordance with generally accepted accounting principles consistent with those applied in the preparation of the most recent audited consolidated financial statements of the company and for such purposes the amount of any dividends paid in other than cash or shares of the company shall be the fair market value of such dividends as determined by the directors; 6 m ; escrow funds means the gross proceeds of the private placement, less the commission or fee payable to the underwriters and less the underwriters' expenses pursuant to the underwriting agreement, which will be deposited with the trustee and disbursed pursuant to section 9 and includes all interest or other income earned thereon; n ; expiry date means the earlier of: i ; the fifth business day after the clearance date; and ii ; august 10, 2003; o ; expiry time means 5: 00 toronto time ; on the expiry date; p ; indenture , herein , hereto, hereunder , hereof , hereby and similar expressions mean or refer to this indenture and not to any particular article, section, subsection, paragraph, clause, subdivision or portion hereof and include any indenture, deed or instrument supplemental or ancillary hereto; and the expressions article , section , subsection and paragraph followed by a number mean and refer to the specified article, section, subsection or paragraph of this indenture; q ; private placement means the private placement of up to 3, 810, 000 special warrants pursuant to the underwriting agreement; r ; prospectus means a final prospectus of the company filed with the commissions by the company which qualifies the proposed distribution of the shares and warrants comprising the units in the designated provinces pursuant to the exercise of the special warrants; s ; purchase price means $ 10 per special warrant for 3, 762, 000 special warrants and $ 30 per special warrant for 48, 000 special warrants; t ; qualification deadline means 5: 00 toronto time ; on june 10, 2003 or such other date as may be specified by the underwriters and the company with notice to the trustee; u ; share means a previously unissued common share which forms part of the unit to be issued to a special warrantholder upon exercise or deemed exercise of a special warrant; v ; special warrant means a special warrant of the company created by the company and issued hereunder for a purchase price of $ 10 per special warrant for 3, 762, 000 special warrants and $ 30 per special warrant for 48, 000 special warrants and entitling the holder thereof to acquire one unit upon exercise or deemed exercise thereof, subject to adjustment in accordance with this indenture upon exercise without payment of additional consideration; w ; special warrant certificate means a certificate evidencing one or more special warrants issuable hereunder, substantially in the form attached hereto as schedule a ; x ; special warrantholder means the registered holder from time to time of an outstanding special warrant; y ; subsidiary of the company means a corporation of which voting securities carrying a majority of the votes attached to all outstanding voting securities are owned, directly or indirectly, by the company or by one or more subsidiaries of the company, or by the company and one or more subsidiaries of the company, and, as used in this definition, voting securities means securities, other than debt securities, carrying a voting right to elect directors either under all circumstances or under some circumstances that may have occurred and are continuing; z ; trading day means any day on which the facilities of the toronto stock exchange, or, if the common shares are not listed thereon, the facilities of any stock exchange on which the common shares are listed, are open for trading; 7 aa ; trustee means the company's registrar and transfer agent, pacific corporate trust company, having an office at 10th floor, 625 howe street, vancouver, british columbia v6c 3b8; bb ; underwriters means, collectively, yorkton securities inc, sprott securities inc, td securities inc and first associates investments inc; cc ; underwriting agreement means the underwriting agreement dated april 10, 2003 between the company and the underwriters whereby the underwriters agreed to act as underwriters of the company in relation to the private placement; dd ; unit means a unit comprised of one share and one-half of one warrant, issued on exercise or deemed exercise of each special warrant, subject to adjustment in accordance with this indenture.
Correspondence with Descartes became the passions, also because Descartes attributed Elizabeth's ailments to an emotional disturbance. After a discussion of Seneca's De vita beata Descartes wrote what would become Les passions de l' me 1649 ; , a first draft of which he submitted to Elizabeth 25 April 1646, 15 May 1646, AT IV, 403414 ; . Occasionally Elizabeth' letters to Descartes also concern family matters: the conversion of her brother Edward 1625-1663 ; to Roman Catholicism [30 November 1645], AT IV 335336 ; and the illness of her sister Henriette-Marie 16261651 ; [21 February 1647], AT IV, 618 ; . Elizabeth continued her correspondence with Descartes also after she left the United Provinces. Her youngest sister Sophie the mother of George I of England 16601727 forwarded some of Descartes' letters to Elizabeth from The Hague. In any case the addressee of three letters of Descartes is almost certainly Sophie [September] 1646, [November 1646], [December] 1646, AT IV, 495496, 533, 592 ; . Elizabeth and Descartes remained close friends until his death in 1650. The proposal of Hector-Pierre Chanut 16011662 ; to edit Elizabeth's correspondence with Descartes--a plan which to a certain extent was also entertained by Descartes himself to Elizabeth, June 1649, AT IV 360 ; --was rejected by Elizabeth Baillet, II, 428 AT V, 474475 ; . Her letters were restituted to her through the ambassador of Brandenburg in the spring of 1650 Chanut to Elizabeth, 16 April 1650, quoted in AT V, 472474 ; . Still, Elizabeth's correspondence with Descartes was copied without her permission. The only known manuscript copy of these letters, made at the end of the 17th or the beginning of the 18th century, was discovered around 1875 ; by the antiquarian bookseller Frederik Muller 18171881 ; in the library of the castle of Rosendael near Arnhem ; , then the property of Baron Reinhardt Jan Christiaan van Pallandt van Keppel 18261899 ; . This manuscript copy is now preserved in Arnhem Rosendael castle, Collection `Stichting Vrienden der Geldersche Kasteelen' ; . Elizabeth's letters to Descartes were published after this copy by Foucher de Careil 18261891 ; in 1879.
Trademark Register for a listing of U.S. trademarks registered and renewed since 1881 and The Directory of U.S. Trademarks for U.S. registrations and information regarding pending applications. 4 While every drug receives three names--a chemical name, a non-proprietary generic ; name, and a brand, or trademark name--each involving distinctly separate processes, this paper will focus primarily on trade names for prescription drugs with some reference to generics as a comparator. Although the three names exist partially to avoid confusion, we will see in later sections how they sometimes inevitably engender it. See Linda Gunderson, The Complex Process of Naming Drugs, Annals of Internal Medicine. October 15, 1998. 5 Cynthia H. Starr, When Drug Names Spell Trouble, Drug Topics, No. 10, Vol. 144; p. 49. May 15, 2000. The monetary and reputational costs of changing drug names after such an incident is both costly and damaging to marketability. A product name associated with adverse effect, even if it had nothing to do with the safety and effectiveness of the drug itself, is harmful to its perception and can affect demand. 6 "Too Similar Drug Names Causing Pharmaceutical Mishaps, Legal Headaches." Chicago Tribune. August 1, 2000. 7 The Patent Restoration Act states that the patent can be renewed up to 5 years from the time of patent issue to the date of FDA approval in addition to the 17-year protection period. During that time, only the manufacturer, or those companies licensed by the original manufacturer, are allowed to market the drug. After the patent expires, however, any company can manufacture and sell the drug, but under the generic or a different trade name. Trade name drugs are more expensive than generic ones because the manufacturer must protect its initial investment which went into the discovery of the new drug. Generic firms do not invest in development so they can sell the drug cheaply. For example, the tranquilizer Miltown when sold under.
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Cont'd Original Indicator 25. All hospitalized patients should receive treatment with methylxanthines. Modified Indicator -- All hospitalized patients should receive treatment with methylxanthines. Comments UNCHANGED DROPPED due to low validity score from panelists. UNCHANGED UNCHANGED WORDING ADDED TO IMPROVE OPERATIONALIZATION OF INDICATOR. UNCHANGED DROPPED due to low validity score from panelists. UNCHANGED DROPPED due to low validity score from panelists. Sedative drugs are appropriate for patients on a ventilator. Panelists felt indicator should be tied to severity and that there should be planned visits in addition to acute visits. Panelists felt that telephone contact is an acceptable form of follow-up. UNCHANGED UNCHANGED and hoodia.
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Field efficacy Field efficacy studies were run globally under field-use conditions in cattle injectable and pour-on ; , swine injectable ; and sheep injectable ; , and these studies demonstrated that the recommended dose could be used safely under diverse field conditions. For example, in North America, doramectin pour-on ; was examined for safety and efficacy against nematodes at seven sites representative of climatic conditions and management systems in a total of 336 cattle. No adverse reaction to treatment was observed in any doramectin-treated animal, and the reduction in faecal egg counts across all studies was 99.7% Conder et al., 1998 and misoprostol.
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Radioactive iodine uptake test. This test measures the amount of radioactive iodine I131 ; which the thyroid gland metabolizes. The patient is given radioactive iodine orally or intravenously. Then, a scintillation camera scans the thyroid gland and produces a pattern which shows the size of the gland. If the patient is given radioactive iodine orally, the test will be done twenty-four hours later. Iodine administered intravenously allows the test to be performed thirty minutes later. There are no fluid or food restrictions for a patient having this test. Several factors affect the test results causing the results to be invalid. These factors include: 1 The patient has been taking drugs and estrogens containing iodine in the last thirty days adrenocorticosteroids, sulfonamide, contraceptives ; . 2 The patient has had x-ray studies using iodine containing media. 3 The patient has eaten a lot of seafood recently. c ; Thyrotropin test TSH ; . This test measure the thyroid gland response to pituitary hormone stimulus. 2-3. DISEASES OF THE ADRENAL GLANDS a. Addison's Disease Adrenal Hypofunction ; . 1 ; Description. Addison's disease is a condition resulting from adrenocortical insufficiency; that is, the adrenal gland is not functioning enough. The adrenal gland has either degenerated or stopped functioning. 2 ; Signs and symptoms. Typical signs and symptoms include: a ; Weakness, fatigue, weight loss. b ; Swollen lymph nodes. c ; Conspicuous bronze coloration of light-colored skin and esomeprazole.
September was Prostate Cancer Awareness Month, and the AUA and AUA Foundation had the unique opportunity to kick off the month by helping to open the NASDAQ Stock Market on Friday, September 1. Executives from both organizations joined industry leaders and political figures, including former New York City Mayor and prostate cancer survivor Rudy Giuliani, in ringing the opening bell at 9: 30 a.m. AUA President Dr. Lawrence S. Ross, Foundation Executive Director John Huber and I were invited to this event by representatives from Cytogen Corp. Leaders from other patient organizations such as the American Cancer Society, Prostate Cancer Foundation and UsToo International were also present. This high profile opportunity allowed the AUA to participate in the promotion of proper screening, diagnosis and treatment of prostate cancer, and was a strong step toward increased awareness of urological diseases and patient education initiatives from the Foundation. "Recognizing that proper screening and diagnosis can save your life is key to being a prostate cancer survivor, " says Mr. Giuliani. In addition to ringing the opening bell, we attended a special reception with Mr. Giuliani and media interviews to raise awareness about prostate cancer.
Uphill The answer must be interpreted strictly. We only want to know about pain when walking uphill or hurrying - not when doing any other activity. Pain experienced only when going up stairs should be recorded as "No". WalkDo If the respondent says they take a tablet eg GTN, nitroglycerin, trinitrin ; or mouthspray for the heart and not for the wheeze ; , code 1 ie they stop walking ; . PainAway If the pain goes away after taking a tablet, or mouthspray then code 1 ie the pain goes away after stopping and taking medicines ; . ShowPain Please be as precise as possible, using the diagram as a guide. Be careful about which side is left and which is right. The numbers on the diagram match the numbers that need to be coded here. SevPain Do not give the respondent any guidance about what is meant by a severe pain across the front of the chest. DocWhat If the doctor said the pain was "nothing to worry about" then enter code 4. ECGEver An ECG measures the electric current generated by the heart muscle. Electrodes are connected to the left side of the front of the chest, and to the wrists and ankles. The subject does not feel any sensations during the test, and is asked to relax and lie still. The electrodes are attached to an ECG machine, which is the size of a video-recorder, usually on a trolley. This records the rhythm of the heart. The test only takes about 20 minutes. It is important to distinguish this test from the 24 hour Ambulatory Holter-Monitor test which is used to investigate transient types of heart rhythm abnormalities. Flegm If the respondent does not know what phlegm is, give the following description: "Phlegm is a thick substance which is coughed up from deep in the chest" Phlegm from the chest or throat must be distinguished from pure nasal discharge - exclude phlegm from the nose, but include phlegm swallowed. Phlegm with first smoke or on first going out of doors should be coded "Yes". Stress the word "usually" - and note that the reference period is winter. Usually refers to most mornings in most winters. If the respondent works nights, then you can use the words "on getting up" rather than "first thing in the morning". SoBUp-SoLev If respondent answers "sometimes" to any of the breathlessness questions, code SoLev "Yes". LegPain Stress ".pain or discomfort.which comes on when you walk". We are only interested in picking up cardiovascular-related leg-pain i.e. claudication ; , not conditions such as rheumatism, scaiatica and omeprazole.
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The respondent has not made bona fide use of the disputed domain names because of his lack of authorization to use the acomplia and zimulti trademarks and rabeprazole.
H. The only dierence among patients is the heterogeneity in the preference parameter . In the pharmaceutical market for this particular condition there are two .rms producing one drug each. An incumbent .rm i is producing a drug of known quality hi , as it has been in the market su ciently long for its quality to have been resolved through earlier Phase IV trials. The incumbent is now facing new competition from an entrant .rm j producing a drug 3.
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Table 2. Placebo-Subtracted Changes From Baseline by Quartiles.
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USA 1996; 93: 1464853. Graham DY, Yamaoka Y. Disease-specific Helicobacter pylori virulence factors: the unfulfilled promise. Helicobacter 2000; 5 Suppl 1: S39, discussion S2731. 19. Wu A, Crabtree J, Bernstein L, et al. Role of Helicobacter pylori Cag A + strains and risk of adenocarcinoma of the stomach and esophagus [abstract]. Gastroenterology 2001; 120: A14. 20. Cover TL. The vacuolating cytotoxin of Helicobacter pylori. Mol Microbiol 1996; 20: 2416. Peek RM Jr, Thompson SA, Donahue JP, et al. Adherence to gastric epithelial cells induces expression of a Helicobacter pylori gene, iceA, that is associated with clinical outcome. Proc Assoc Amer Physicians 1998; 110: 53144. Go MF, Crowe SE. Virulence and pathogenicity of Helicobacter pylori. Gastroenterol Clin N Amer 2000; 29: 64970. Vorobjova T, Maaroos HI, Sipponen P, et al. Apoptosis in different compartments of antrum and corpus mucosa in chronic Helicobacter pylori gastritis. An 18-year followup study. Scand J Gastroenterol 2001; 36: 13643. Peterson WL, Barnett CC, Evans DJ Jr, et al. Acid secretion and serum gastrin in normal subjects and patients with duodenal ulcer disease: the role of Helicobacter pylori. Amer J Gastroenterol 1993; 88: 203843. Schultze V, Hackelsberger A, Gunther T, et al. Differing patterns of Helicobacter pylori gastritis in patients with duodenal, prepyloric, and gastric ulcer disease. Scand J Gastroenterol 1998; 33: 13742. El-Omar EM, Oien K, El-Nujumi A, et al. Helicobacter pylori infection and chronic gastric acid hyposecretion. Gastroenterology 1997; 113: 1524. Price AB. The Sydney System: histological division. J Gastroenterol Hepatol 1991; 6: 20922. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. J Surg Pathol 1996; 20: 116181. Warren JR. Gastric pathology associated with Helicobacter pylori. Gastroenterol Clin N Amer 2000; 29: 70551. Sipponen P, Kekki M, Haapakoski J, et al. Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross-sectional data. Int J Cancer 1985; 35: 1737. Scheiman JM, Cutler AF. Helicobacter pylori and gastric cancer. Amer J Med 1999; 106: 2226. Parsonnet J, Hansen S, Rodriguez L, et al. Helicobacter pylori infection and gastric lymphoma. N Engl J Med 1994; 330: 126771. Zucca E, Bertoni F, Roggero E, et al. Molecular analysis of the progression from Helicobacter pylori-associated chronic gastritis to mucosa-associated lymphoid-tissue lymphoma of the stomach. N Engl J Med 1998; 338: 80410. Morgner A, Bayerdorffer E, Neubauer A, Stolte M. Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori. Gastroenterol Clin North Am.
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Departments of 1Clinical Virology, 2Oral Surgery, University of G6teborg, Guldhedsgatan lOb, S-413 46 G6teborg, Sweden and 3Department of Pathology and Microbiology, University of Nebraska Medical Center and Eppley Institute for Research on Cancer and Allied Diseases, Omaha, Nebraska 68182, U.S.A. Accepted 6 March 1989.
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Comparing benefits of surgical treatments for degenerative spinal disease Dr. Hrtl's study in April Journal of Neurosurgery: Spine; engendered by press release ; Tips for expectant mothers on picking an ob-gyn Replication of male genome may help men with very low sperm counts become fathers. Dr. Takeuchi's study presented at 23rd annual conference of the European Society of Human Reproduction and Embryology ; Are non-drug treatment options adequately available to children with mental or emotional health problems? Comment on Technology in Cancer Research and Treatment TCRT ; study on treating prostate cancer with irreversible electroporation ablation Comment on study in journal Cardiovascular Research reporting on adult stem cells used for creating blood vessels Dr. Aronne testified at a Wednesday, June 13, FDA approval hearing on the weightloss drug Izmulti Sneak peek at the new U.S. Centers for Medicare and Medicaid Services CMS ; hospital mortality rates for heart failure and heart attacks.
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Bellagio Conference on Emergency Contraception. Consensus statement on emergency contraception. Contraception 52 1995 ; . This statement reports the outcome of an international meeting on emergency contraception. Consortium for Emergency Contraception. Expanding Global Access to Emergency Contraception. Seattle: PATH 2000 ; . English and Spanish versions available through the Consortium website at cecinfo . This publication provides an overview of the consortium's work to introduce a dedicated emergency contraception project in seven countries. It includes a history of the consortium's development, profiles of introduction efforts, updated medical and service-delivery guidelines, and additional resources for family planning programs. Consortium for Emergency Contraception. Emergency Contraceptive Pills: A Resource Packet for Health Care Providers and Programme Managers. Seattle: PATH 1997 ; . This resource packet contains an extensive array of materials on emergency contraceptive pills ECPs ; including: suggestions for how to adapt resource packet materials for local use; a framework outlining key issues that should be considered before introducing ECPs through family planning, reproductive health, and other delivery systems; questions and answers for decision makers; prototype client brochures that describe in simple language what ECPs are and how they are used; and selected references on key studies that address ECP safety, efficacy, and use. Online versions of packet materials are available on the consortium website cecinfo ; . Farrell, B. et al. Emergency Contraceptive Pills: A Comprehensive Training Course. Watertown, Massachusetts: Pathfinder International Medical Services, Training Module Number 5 May 1997 ; . Although well-documented and safe, emergency contraceptive pills ECPs ; have not received significant attention or use until recently. ECPs can play a crucial role in family planning programs, providing a safe method of avoiding unwanted pregnancy after unprotected intercourse, as well as a bridge to continuing contraception. This training module will prepare providers to offer ECP services to family planning clients. FHI. Emergency contraceptive pills. Network 21 1 ; 2001 ; . Available at: fhi en fp fppubs network v21-1 index . Emergency contraceptive methods can prevent pregnancy after unprotected intercourse, method failure, or incorrect method use. In the past five years, major international reproductive health organizations, including WHO, have worked to make emergency contraception more widely available, increase the knowledge of providers and consumers about this method, and study unresolved research issues. This issue of Network describes how EC works, research efforts underway to improve ease of use and reduce side effects, and issues to be considered for program supply. Glasier, A. and Baird D. The effects of self-administering emergency contraception. New England Journal of Medicine 239 1 ; : 14 July 2, 1998 ; . The authors compared the use of emergency contraceptive pills ECPs ; in 553 women who were provided with a replaceable supply of hormonal emergency contraceptive pills to be taken at home the treatment group ; , and 530 women who could obtain ECPs through a doctor the control group ; . The study found that the women in the treatment group were no more likely to use emergency contraception repeatedly than the women in the control group, and that nearly all women used emergency contraception correctly. The authors conclude that making emergency contraception more easily obtainable does not pose any risks or increase the likelihood of repeat use. Furthermore, because the efficacy of ECPs decreases over time since unprotected intercourse, increased availability of emergency contraception may reduce the rate of unwanted pregnancies. International Planned Parenthood Federation IPPF ; . IMAP statement on emergency contraception. IPPF Medical Bulletin. 2004; 38 4 ; : 13. Available at: ippf medical bulletin pdf Vol38No1March2004en . This Bulletin contains the statement that was revised by the IPPF International Medical Advisory Panel IMAP ; after the October 2003 meeting. The bulletin reviews current knowledge about the method, mechanism of action, efficacy, eligibility criteria, and side effects. In addition, the following points are emphasized: family planning associations should strive to promote and provide emergency contraception in their countries; prompt, easy access to EC is crucial; the sooner.
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